Scientific Articles

Investigators in the Medically Associated Science and Technology (MAST) program are frequently published in leading peer-reviewed journals, and their groundbreaking research is regularly featured in the news. These selected publications provide insight into the breadth of research performed by the MAST team. Please click on them to read.

2023:

Type 2 Diabetes and the Microbiome

Probiotics in Functional Dyspepsia

Prevalence of Small Intestinal Bacterial Overgrowth Syndrome in Patients with Non-Alcoholic Fatty Liver Disease/Non-Alcoholic Steatohepititis: A Cross-Sectional Study

Defining Small Intestinal Bacterial Overgrowth by Culture and High Throughput Sequencing

Antivinculin Antibodies in Systemic Sclerosis: AssociationsWith Slow Gastric Transit and Extraintestinal Clinical Phenotype

Interleukin-10 Knockout Mice Do Not Reliably Exhibit Macroscopic Inflammation: A Natural History Endoscopic Surveillance Study

Safety and Tolerability of High-Resolution Esophageal Manometry in Children and Adults

IBS Is Not Associated with an Increased Risk of Polyps and Colorectal Cancer: A Systematic Review and Meta-Analysis

Consuming artificial sweeteners may alter the structure and function of duodenal microbial communities

Coronavirus Disease 2019 (COVID-19) Pandemic Lifestyle Changes May Have Influenced Small Bowel Microbial Composition and Microbial Resistance

Hydrogen Sulfide Producers Drive a Diarrhea-Like Phenotype and a Methane Producer Drives a Constipation-Like Phenotype in Animal Models

Cytolethal distending toxin B inoculation leads to distinct gut microtypes and IBS-D-like microRNA-mediated gene expression changes in a rodent model

2022:

Bile acid and gut microbiota in irritable bowel syndrome

Smoking has disruptive effects on the small bowel luminal microbiome

Effects of proton pump inhibitors on the small bowel and stool microbiomes

Campylobacter infection and the link with Irritable Bowel Syndrome

Methanogens and hydrogen sulfide producing bacteria guide distinct gut microbe profiles and IBS subtypes

Exhaled methane is associated with a lower heart rate

A single fasting exhaled methane level correlates with fecal methanogen load, clinical symptoms and accurately detects intestinal methanogen overgrowth

Duodenal microbiome changes in postmenopausal women: effects of hormone therapy and implications for cardiovascular risk

SIBO can form an indigenous proinflammatory environment in the duodenum: a prospective study

A smartphone application using artificial intelligence is superior to subject self-reporting when assessing stool

The response of the rodent gut microbiome to broad-spectrum antibiotics is different in males and females

UV-A light increases mitochondrial anti-viral signaling protein in confluent human tracheal cells…

2021

Leite G, Pimentel M, Barlow GM, Chang C, Hosseini A, Wang J, Parodi G, Sedighi R, Rezaie A, Mathur R. Age and the aging process significantly alter the small bowel microbiome. Cell Rep. 2021 Sep 28;36(13):109765.
Leite G, Pimentel M, Mathur R, Barlow GM, Chan Y, Melmed GY, Rezaie A. Ultraviolet-A light reduces cellular cytokine release from human endotracheal cells infected with Coronavirus. Photodiagnosis Photodyn Ther. 2021 Sep;35:102457.
Leite G, Rezaie A, Mathur R, Barlow GM, Melmed GY, Pimentel M. Ultraviolet-A light increases mitochondrial anti-viral signaling protein in confluent human tracheal cells via cell-cell signaling. J Photochem Photobiol B. 2021 Nov 13;226:112357.
Rezaie A, Melmed GY, Leite G, Mathur R, Takakura W, Pedraza I, Lewis M, Murthy R, Chaux G, Pimentel M. Endotracheal Application of Ultraviolet A Light in Critically Ill Patients with Severe Acute Respiratory Syndrome Coronavirus 2: A First-in-Human Study. Adv Ther. 2021 Aug;38(8):4556-4568.
Barlow JT, Leite G, Romano AE, Sedighi R, Chang C, Celly S, Rezaie A, Mathur R, Pimentel M, Ismagilov RF. Quantitative sequencing clarifies the role of disruptor taxa, oral microbiota, and strict anaerobes in the human small-intestine microbiome. Microbiome 2021, 9:214.
Leite G, Pimentel M, Barlow GM, Mathur R. The small bowel microbiome changes significantly with age and aspects of the ageing process. Microb Cell. 2021 Dec 27;9(1):21-23.
Suliman Y, Kafaja S, Oh SJ, Alemam M, Bagnato G, Abignano G, Singh RR, Barlow G, Liu X, Valera I, Morales W, Rezaie A, Pimentel M, Del Galdo F, Furst DE. Anti-vinculin antibodies in scleroderma (SSc): a potential link between autoimmunity and gastrointestinal system involvement in two SSc cohorts. Clin Rheumatol. 2021 Jun;40(6):2277-2284.
Moosavi S, Pimentel M, Wong MS, Rezaie A. Irritable Bowel Syndrome in Pregnancy. Am J Gastroenterol. 2021 Mar 1;116(3):480-490.
Lacy BE, Pimentel M, Brenner DM, Chey WD, Keefer LA, Long MD, Moshiree B. ACG Clinical Guideline: Management of Irritable Bowel Syndrome. Am J Gastroenterol. 2021 Jan 1;116(1):17-44.
Tziatzios G, Gkolfakis P, Papanikolaou IS, Mathur R, Pimentel M, Damoraki G, Giamarellos-Bourboulis EJ, Dimitriadis G, Triantafyllou K. High Prevalence of Small Intestinal Bacterial Overgrowth among Functional Dyspepsia Patients. Dig Dis. 2021;39(4):382-390.

2020

Leite G, Morales W, Weitsman S, Celly S, Parodi G, Mathur R, Barlow GM, Sedighi R, Millan MJV, Rezaie A, Pimentel M. The duodenal microbiome is altered in small intestinal bacterial overgrowth. PLoS One. 2020 Jul 9;15(7):e0234906.
Leite GGS, Weitsman S, Parodi G, Celly S, Sedighi R, Sanchez M, Morales W, Villanueva-Millan MJ, Barlow GM, Mathur R, et al. Mapping the Segmental Microbiomes in the Human Small Bowel in Comparison with Stool: A REIMAGINE Study. Dig Dis Sci. 2020 Sep;65(9):2595-2604. doi: 10.1007/s10620-020-06173-x. Epub 2020 Mar 6. PMID: 32140945; PMCID: PMC7419378.
Rezaie A, Leite GGS, Melmed GY, Mathur R, Villanueva-Millan MJ, Parodi G, Sin J, Germano JF, Morales W, Weitsman S, Kim SY, Park JH, Sakhaie S, Pimentel M. Ultraviolet A light effectively reduces bacteria and viruses including coronavirus. PLoS One 2020 Jul 16;15(7):e0236199. doi: 10.1371/journal.pone.0236199. eCollection 2020. PMID 32673355.
Takakura W, Pimentel M. Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome – An Update. Front Psychiatry. 2020 Jul 10;11:664. doi: 10.3389/fpsyt.2020.00664. PMID: 32754068; PMCID: PMC7366247.
Oh SJ, Pimentel M, Leite G, Celly S, Villanueva-Millan MJ, Lacsina I, Chuang B, Parodi G, Morales W, Weitsman S, Singer-Englar T, Barlow GM, Zhai J, Pichetshote N, Rezaie A, Mathur R, Pimentel M. Acute Appendicitis is Associated with Appendiceal Microbiome Changes Including Elevated Campylobacter jejuni Levels. BMJ Open Gastroenterol. 2020 Jun;7(1):e000412. doi: 10.1136/bmjgast-2020-000412. PMID 32499276.
Morales W, Triantafyllou K, Parodi G, Weitsman S, Park SC, Rezaie A, Pichetshote N, Lin E, Pimentel M. Immunization with cytolethal distending toxin B produces autoantibodies to vinculin and small bowel bacterial changes in a rat model of postinfectious irritable bowel syndrome. Neurogastroenterol Motil. 2020;32(10):e13875.
Takakura W, Oh SJ, Singer-Englar T, Mirocha J, Leite G, Fridman A, Pimentel M, Mathur R, Pichetshote N, Rezaie A. Comparing the rates of methane production in patients with and without appendectomy: results from a large-scale cohort. Sci Rep. 2020 Jan 21;10(1):867.
Pimentel M, Saad RJ, Long MD, Rao SSC. ACG Clinical Guideline: Small Intestinal Bacterial Overgrowth. Am J Gastroenterol. 2020 Feb;115(2):165-178.
Pimentel M, Lembo A. Microbiome and Its Role in Irritable Bowel Syndrome. Dig Dis Sci. 2020 Mar;65(3):829-839.
Lembo A, Rao SSC, Heimanson Z, Pimentel M. Abdominal Pain Response to Rifaximin in Patients With Irritable Bowel Syndrome With Diarrhea. Clin Transl Gastroenterol. 2020 Mar;11(3):e00144.
Tziatzios G, Gkolfakis P, Papanikolaou IS, Mathur R, Pimentel M, Giamarellos-Bourboulis EJ, Triantafyllou K. Gut Microbiota Dysbiosis in Functional Dyspepsia. Microorganisms. 2020 May 8;8(5):691.
Leite G, Morales W, Weitsman S, Celly S, Parodi G, Mathur R, Barlow GM, Sedighi R, Millan MJV, Rezaie A, Pimentel M. The duodenal microbiome is altered in small intestinal bacterial overgrowth. PLoS One. 2020 Jul 9;15(7):e0234906.
Gu P, Patel D, Lakhoo K, Ko J, Liu X, Chang B, Pan D, Lentz G, Sonesen M, Estiandan R, Lin E, Pimentel M, Rezaie A. Breath Test Gas Patterns in Inflammatory Bowel Disease with Concomitant Irritable Bowel Syndrome-Like Symptoms: A Controlled Large-Scale Database Linkage Analysis. Dig Dis Sci. 2020 Aug;65(8):2388-2396.
Quigley EMM, Murray JA, Pimentel M. AGA Clinical Practice Update on Small Intestinal Bacterial Overgrowth: Expert Review. Gastroenterology. 2020 Oct;159(4):1526-1532.

Pre-2020

Morales W, Rezaie A, Barlow G, Pimentel M. Second-generation biomarker testing for irritable bowel syndrome using plasma anti-CdtB and anti-vinculin levels. Dig Dis Sci. 2019 May 31
Pimentel M, Lembo A, Chey W, Zakko S, Ringel Y, Yu J, Mareya S, Shaw A, Bortey E, Forbes WP. Rifaximin therapy for patients with irritable bowel syndrome without constipation. N Engl J Med. 2011;364(1):22-32.
Pimentel M, Morales W, Rezaie A, Marsh E, Lembo A, Mirocha J, Leffler DA, Marsh Z, Weitsman S, Chua KS, et al. Development and validation of a biomarker for diarrhea-predominant irritable bowel syndrome in human subjects. PLOS One. 2015 May 13;10(5):e0126438.
Rezaie A, Park SC, Morales W, Marsh E, Lembo A, Kim JH, Weitsman S, Chua KS, Barlow GM, Pimentel M. Assessment of anti-vinculin and anti-cytolethal distending toxin B antibodies in subtypes of irritable bowel syndrome. Dig Dis Sci.2017;62(6):1480-1485.
Chan J, Pall M, Pisarska M, Mathur R, EzeH U, Azziz R. Screening for androgen excess in women: accuracy of self-reported excess body hair growth and menstrual dysfunction. J Clin Endocrinol Metab. 2020 May 22:dgz264. doi: 10.1210/clinem/dgz264. PMID 32442282.
Ezeh U, Arzumanyan Z, Lizneva D, Mathur R, Chen YH, Boston RC, Chen YI, Azziz R. Alterations in plasma non-esterified fatty acid (NEFA) kinetics and relationship with insulin resistance in polycystic ovary syndrome. Hum Reprod. 34(2):335-344, 2019. PMID 30576500.
Mathur R, Chua KS, Mamelak M, Morales W, Barlow GM, Thomas R, Stefanovski D, Weitsman S, Marsh Z, Bergman RN, Pimentel M. Metabolic effects of eradicating breath methane using antibiotics in prediabetics subjects with obesity. Obesity (Silver Spring). 2016 Mar;24(3):576-582.
Mathur R, Kim G, Morales W, Sung J, Rooks E, Pokkunuri V, Weitsman S, Barlow GM, Chang C, Pimentel M. Intestinal Methanobrevibacter smithii but not total bacteria is related to diet-induced weight gain in rats. Obesity (Silver Spring). 2013 Apr;21(4):748-754.

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